About the MWUPCE
The 九色视频 Pharmacometrics Center of Excellence (MWUPCE) partners strong faculty knowledge base in computer modeling of drug efficacy and toxicity with wet-lab analytic approaches. Together, the group is highly expert conducting pre-clinical through post-marketing studies. The Center builds on the existing synergies in the University's Core Facilities.
Learn more about the Downers Grove Core Research Facility
Mission
The mission of the MWUPCE is to:
- Design innovative strategies that maximize safe and effective pharmacotherapy for patients
- Develop the next generation of translational clinicians and scientists through advanced pharmacometric education.

Meet the Investigators
Dr. Andurkar serves as Professor and Chair of the Department of Pharmaceutical Sciences. He earned his M.S. and Ph.D. in Medicinal Chemistry from Auburn University, Department of Pharmaceutical Sciences. He completed his postdoctoral studies at the University of Houston, Department of Chemistry. Dr. Andurkar has more than 25 years of experience in the design, synthesis, isolation and purification, structural elucidation, drug metabolism, and pharmacological studies of bioactive molecules. His current research interests are in the design, synthesis, and pharmacological evaluation of novel analgesics and antiepileptic agents, as well as the study of novel synthetic organic chemical methodologies, stereoselective synthesis, and evaluating the impact of stereochemistry on biological activity. He serves as scientific advisor to Aagami Inc., and Pharmazz Inc.

Dr. Howard L. Chhen is an Infectious Diseases Translational Research Fellow at 九色视频 College of Pharmacy-Glendale Campus, and he is a member of the Pharmacometrics Center of Excellence. He practices as an Infectious Diseases pharmacist at HonorHealth John C. Lincoln Medical Center in Phoenix, AZ. He obtained his Doctor of Pharmacy in 2023 from the University of Wisconsin 鈥 Madison. He completed his PGY-1 Pharmacy Practice Residency at the University of Michigan Health 鈥 Sparrow Hospital. He is engaged in various clinical and in vitro research including pharmacokinetic/pharmacodynamic models and treatment of multidrug-resistant infections as well as teaching. He serves on the Society of Infectious Diseases Pharmacists Interorganizational and Engagement Committee.

Dr. Medha D. Joshi is an Associate Professor in Pharmaceutical Sciences at 九色视频's College of Pharmacy, Glendale Campus. Dr. Joshi has expertise in lipid based drug delivery systems including solid lipid nanoparticles (SLN), micro emulsions, self-emulsifying drug delivery systems (SMEDDs), nanosuspensions, and liposomes etc. targeted drug delivery. Her research program at Midwestern university is focused on application of nanoparticulate targeted delivery a) to neurogenetic peptides for their delivery to the blood brain barrier, and b) reduction of maternal-fetal toxicity of drugs across the placental barrier. She has more than 30 peer-reviewed research articles, two patents, and three book chapters to her credit. She has been a principle investigator and co-investigator on several intramural and extramural grants, including the Alzheimer's Drug Discovery Foundation and NIH AREA grants.

Dr. Gwendolyn Pais is a Research Assistant Professor in the College of Pharmacy and a Scientist within the 九色视频 Pharmacometrics Center of Excellence. Dr. Pais earned her Ph.D. from the University of Illinois at Chicago. She completed her postdoctoral training in Pharmacology at 九色视频. Her research focuses on preventing drug-induced kidney and neurologic toxicity. She is particularly interested in defining optimal exposures, exposure thresholds and biomarkers of toxicity to facilitate dose escalation in a safe manner. Her laboratory utilizes non-clinical approaches and seeks to translate these data to critically ill pediatric patients. Dr. Pais is actively engaged in pharmacology organizations and serves as a reviewer for multiple peer-reviewed journals.

Dr. Roberts earned a B.S. in Biomedical Engineering from the University of California - Davis and a Ph.D. in Biological Sciences from the Irell & Manella Graduate School of Biological Sciences at City of Hope Medical Center. He then completed his postdoctoral training at the Yale University School of Medicine. Since 2021, Dr. Roberts has been an Assistant Professor of Pharmacology at 九色视频's Downers Grove, IL campus. His research spans two major foci: 1) analysis of the causes of drug resistance among advanced cancers, along with exploring potential novel strategies to overcome that resistance, and 2) building in vitro models for drug research, including gene expression, knockdown, and mutation in cell lines for functional studies. The long-term goals of the Roberts Lab are to create better drugs, better screening tools, and a better understanding of how to combat neoplastic and infectious diseases. In addition to research, Dr. Roberts participates in the teaching of infectious disease and anti-cancer pharmacology across MWU programs, is a reviewer for multiple peer-reviewed journals, and serves on the executive board of the Great Lakes Chapter of the American Society for Pharmacology and Experimental Therapeutics (GLC-ASPET).

Dr. Adrian Valadez is a Postdoctoral fellow at 九色视频 and a member of the Pharmacometrics Center of Excellence. His focus is on quantitating beta-lactam antibiotic pharmacokinetics and pharmacodynamics (PK/PD). He is enthusiastic about further exploring opportunities within the realm of Infectious Disease research, PK/PD modeling, academia, and pharmaceutical industry. Currently, he is engaged with multiple laboratory methodologies including LC-MS/MS assay development, and population pharmacokinetic modeling and simulation using cutting edge software programs such as Pmetrics and Monolix to analyze drug behavior within the body.

Previous Publications and Presentations
Miglis C, Rhodes NJ, Liu J, Gener J, Hang E, Scheetz M. Quantifying the Importance of Active Antimicrobial Therapy among Patients with Gram-negative Bloodstream Infections: Cefepime as a Representative Agent. International Journal of Antimicrobial Agents. 2018. Epub 2018/10/14. doi: 10.1016/j.ijantimicag.2018.10.004. PubMed PMID: 30315921.
Avedissian SN, Scheetz MH, Zembower TR, Silkaitis C, Maxwell R, Jenkins C, Postelnick MJ, Sutton SH, Rhodes NJ. Measuring the impact of varying denominator definitions on standardized antibiotic consumption rates: implications for antimicrobial stewardship programmes. Journal of Antimicrobial Chemotherapy. 2018;73(10):2876-82. Epub 2018/08/08. doi: 10.1093/jac/dky275. PubMed PMID: 30085084.
Joshi M, Chang J., Hlukhenka K., Pais G., Avedissian S., Gulati A., Prozialeck W, Hubka T., Scheetz MH, Griffin B. (2018) Elucidation of fetal and maternal vancomycin-induced kidney injury using a pregnant rat model, PharmSci 360, November 2018, Washington DC.
Joshi M, Hlukhenka K., Pais G., Prozialeck W, Scheetz M, Griffin B. In vitro evaluation of vancomycin loaded liposomes for its potential of reduced nephrotoxicity in rat epithelial kidney (NRK) cells, ASHP Midyear 2018
Aljefri D, Avedissian S, Rhodes NJ, Postelnick M, Scheetz MH. 1391. Vancomycin Area under the Curve (AUC) to Predict Nephrotoxicity: A systematic Review and Meta-analysis of observational studies. ID Week; San Francisco 2018.
Avedissian S, Liu J, O'Donnell J, Pais G, Becher L, Joshi M, Prozialeck W, Lamar P, Lodise TP, Scheetz MH. 1419. 24-Hour Pharmacokinetic Relationships for Intravenous Vancomycin and Novel Urinary Biomarkers of Acute Kidney Injury. ID Week; San Francisco 2018.
Avedissian S, Rhodes NJ, Liu J, Aljefri D, Postelnick M, Sutton S, Zembower T, Martin D, Pais G, Cruce C, Scheetz MH. 1821. Understanding the components and calculation of the SAAR, Illustrative Data. ID Week; San Francisco 2018.
Cruce C, Postelnick M, Martin D, Sutton S, Wunderink R, Zembower T, Scheetz MH, Rhodes NJ. 209. Impact of a risk-based CAP prescribing guideline paired with antimicrobial stewardship to improve antibiotic prescribing for patients at low risk for drug resistant pathogens. ID Week; San Francisco 2018.
Lee B, Constantino-Corpuz J, Apolinario K, Wang S, Nadler B, Scheetz MH, Rhodes NJ. 1068. Evaluation of Cefazolin versus Anti-Staphylococcal Penicillins for the Treatment of Methicillin-Susceptible Staphylococcus aureus Bloodstream Infections in Acutely-Ill Adult Patients: Results of a Systematic Review and Meta-Analysis. ID Week; San Francisco 2018.
Liu J, Avedissian S, Pais G, Joshi M, Rhodes NJ, Scheetz MH. 1394. A Translational Pharmacokinetic Rat Model of Cerebral Spinal Fluid (CSF) and Plasma Concentrations of Cefepime. ID Week; San Francisco 2018.
Liu J, Mercuro N, Davis S, Yarnold P, Patel T, Petty L, Kaye K, Scheetz MH. 1871. Identifying time periods of high and low vancomycin use. ID Week; San Francisco 2018.